Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08EIX
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| Former ID |
DIB007627
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| Drug Name |
T-686
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| Synonyms |
PAI-1 inhibitor, Tanabe
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| Drug Type |
Small molecular drug
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| Indication | Arteriosclerosis [ICD-11: BD40; ICD-10: I70] | Terminated | [1] | |
| Company |
Tanabe Seiyaku Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C21H19NO5
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| Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)C=C2C(=CC3=CC=CC=C3)C(=O)NC2=O
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| InChI |
1S/C21H19NO5/c1-25-17-11-14(12-18(26-2)19(17)27-3)10-16-15(20(23)22-21(16)24)9-13-7-5-4-6-8-13/h4-12H,1-3H3,(H,22,23,24)/b15-9+,16-10+
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| InChIKey |
YQALUFAJAWGTQV-KAVGSWPWSA-N
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| CAS Number |
CAS 152815-51-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasminogen activator inhibitor (PAI) | Target Info | Inhibitor | [2] |
| KEGG Pathway | HIF-1 signaling pathway | |||
| p53 signaling pathway | ||||
| Hippo signaling pathway | ||||
| Complement and coagulation cascades | ||||
| Chagas disease (American trypanosomiasis) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008057) | |||
| REF 2 | T-686, a novel inhibitor of plasminogen activator inhibitor-1, inhibits thrombosis without impairment of hemostasis in rats. Eur J Pharmacol. 1997 Jul 9;330(2-3):151-6. | |||
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