Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08EAI
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| Former ID |
DIB003061
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| Drug Name |
AS-101
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| Synonyms |
Ossirene; Tellaxium trichloride glycol; IVX-Q-101
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| Drug Type |
Small molecular drug
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 2 | [1], [2], [3] | |
| Company |
Bar-Ilan University
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
CCCN1C2=NC(=C3C=C(NN3C)OC(=O)CNC4=CC(=C(C=C4)OC)OC)N=C2C(=O)N(C1=O)CCC
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 437). | |||
| REF 2 | The tellurium redox immunomodulating compound AS101 inhibits IL-1beta-activated inflammation in the human retinal pigment epithelium. Br J Ophthalmol. 2013 Jul;97(7):934-8. | |||
| REF 3 | The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme. J Interferon Cytokine Res. 2007 Jun;27(6):453-62. | |||
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