Drug Information
Drug General Information | Top | |||
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Drug ID |
D08CKJ
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Former ID |
DIB012702
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Drug Name |
Fonsartan
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Synonyms |
HR-720; Hoe-720
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Discontinued in Phase 2 | [1] | |
Company |
Hoechst Marion Roussel Inc; Hoechst AG
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Structure |
Download2D MOL |
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Formula |
C26H30K2N4O5S2
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Canonical SMILES |
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC(=NCCC)[O-])C(=O)[O-])SC.[K+].[K+]
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InChI |
1S/C26H32N4O5S2.2K/c1-4-6-11-22-28-24(36-3)23(25(31)32)30(22)17-18-12-14-19(15-13-18)20-9-7-8-10-21(20)37(34,35)29-26(33)27-16-5-2;;/h7-10,12-15H,4-6,11,16-17H2,1-3H3,(H,31,32)(H2,27,29,33);;/q;2*+1/p-2
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InChIKey |
WGZNJDWXOFLZKQ-UHFFFAOYSA-L
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Angiotensin II receptor type-2 (AGTR2) | Target Info | Modulator | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Adrenergic signaling in cardiomyocytes | ||||
Renin-angiotensin system | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | ACE Inhibitor Pathway | |||
GPCRs, Class A Rhodopsin-like | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005209) | |||
REF 2 | Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43. |
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