Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08BEO
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| Former ID |
DCL001013
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| Drug Name |
Talampanel
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| Synonyms |
Ampanel; Kinampa; GYKI 53773; LY 300164; GYKI-53773; IDR-53773; LY-300164; Talampanel (INN); (8R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine; (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine; (R)-7-Acetyl-5-(p-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)(2,3)benzodiazepine; (R)-7-acetyl-5-(p-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0] | Phase 2 | [1], [2] | |
| Company |
Teva Pharmaceutical Industries
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H19N3O3
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| Canonical SMILES |
CC1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
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| InChI |
1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
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| InChIKey |
JACAAXNEHGBPOQ-LLVKDONJSA-N
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| CAS Number |
CAS 161832-65-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586262, 10255482, 12015007, 14777784, 14924664, 17396863, 46238690, 48428354, 49963719, 57350439, 76446401, 103066537, 103084697, 103249115, 113454154, 117571463, 126681781, 128245269, 134223402, 134339441, 134340496, 135119253, 142214230, 162799293, 175426925, 179150031, 198945173, 223442255, 223660829, 225092641, 226489989, 241377297, 249582953, 249583802, 252158544, 252166491, 252216371, 252451212
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| ChEBI ID |
CHEBI:34992
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA (GRIA) | Target Info | Antagonist | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8279). | |||
| REF 2 | Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. | |||
| REF 3 | Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model. Epilepsia. 2009 Apr;50(4):694-701. | |||
| REF 4 | Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. | |||
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