Drug Information
Drug General Information | Top | |||
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Drug ID |
D08AID
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Former ID |
DNC013006
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Drug Name |
6-ethyl-3-(2-methylbutoxycarbonyl)-4-quinolone
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Synonyms |
CHEMBL377719
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C17H21NO3
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Canonical SMILES |
CCC1=CC2=C(C=C1)NC=C(C2=O)C(=O)OCC(C)CC
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InChI |
1S/C17H21NO3/c1-4-11(3)10-21-17(20)14-9-18-15-7-6-12(5-2)8-13(15)16(14)19/h6-9,11H,4-5,10H2,1-3H3,(H,18,19)
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InChIKey |
CXKHROTTYJSKQI-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Serotonergic synapse | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transport |
References | Top | |||
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REF 1 | 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. |
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