Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07ZUZ
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| Former ID |
DIB006431
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| Drug Name |
CK-2127107
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| Indication | Amyotrophic lateral sclerosis [ICD-11: 8B60.0] | Phase 2 | [1] | |
| Spinal muscular atrophy [ICD-11: 8B61] | Phase 2 | [1] | ||
| Muscle atrophy [ICD-11: FB32.Y; ICD-9: 728.2] | Phase 1 | [2] | ||
| Company |
Cytokinetics
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H18F2N6O
|
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| Canonical SMILES |
C1C(CC1(CNC2=NC=C(C=N2)N3C=CC(=C3)C(=O)N)C4=C(C=CC=N4)F)F
|
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| InChI |
1S/C19H18F2N6O/c20-13-6-19(7-13,16-15(21)2-1-4-23-16)11-26-18-24-8-14(9-25-18)27-5-3-12(10-27)17(22)28/h1-5,8-10,13H,6-7,11H2,(H2,22,28)(H,24,25,26)
|
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| InChIKey |
MQXWPWOCXGARRK-UHFFFAOYSA-N
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| CAS Number |
CAS 1345410-31-2
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fast skeletal muscle troponin complex (TNNC2) | Target Info | Modulator | [3] |
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Striated Muscle Contraction | |||
| WikiPathways | Striated Muscle Contraction | |||
| Muscle contraction | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037810) | |||
| REF 3 | Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. | |||
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