Drug Information
Drug General Information | Top | |||
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Drug ID |
D07XCF
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Former ID |
DIB004561
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Drug Name |
Benfluorex
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Synonyms |
Benfluorex hydrochloride; 23642-66-2; Mediaxal; Lipophoral; Balans; Benfluorex (hydrochloride); EINECS 245-801-8; 2-((1-(3-(Trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride; NCGC00094832-01; 2-(alpha-Methyl-3-(trifluoromethyl)phenylethylamino)ethyl benzoat; DSSTox_CID_25854; DSSTox_RID_81175; DSSTox_GSID_45854; W-110575; 2-((alpha-Methyl-m-(trifluoromethyl)phenethyl)amino)ethanol benzoate (ester); Benfluorex HCl; 2-{(1-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL}AMINO)ETHYL BENZOATE HYDROCHLORIDE
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Drug Type |
Small molecular drug
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Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Withdrawn from market | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H20F3NO2
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Canonical SMILES |
CC(CC1=CC(=CC=C1)C(F)(F)F)NCCOC(=O)C2=CC=CC=C2
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InChI |
1S/C19H20F3NO2/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16/h2-9,13-14,23H,10-12H2,1H3
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InChIKey |
CJAVTWRYCDNHSM-UHFFFAOYSA-N
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CAS Number |
CAS 23602-78-0
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:93826
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Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
Studied Microbe: Akkermansia muciniphila
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Akkermansia muciniphila was decreased by Benfluorex hydrochloride (adjusted p-values: 7.07E-03). |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. |
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