Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07TEP
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| Former ID |
DCL000979
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| Drug Name |
SCH 420814
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| Synonyms |
Preladenant; SCH-420814
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Phase 2 | [1], [2] | |
| Company |
Schering-Plough
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H29N9O3
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| Canonical SMILES |
COCCOC1=CC=C(C=C1)N2CCN(CC2)CCN3C4=C(C=N3)C5=NC(=NN5C(=N4)N)C6=CC=CO6
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| InChI |
1S/C25H29N9O3/c1-35-15-16-36-19-6-4-18(5-7-19)32-11-8-31(9-12-32)10-13-33-23-20(17-27-33)24-28-22(21-3-2-14-37-21)30-34(24)25(26)29-23/h2-7,14,17H,8-13,15-16H2,1H3,(H2,26,29)
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| InChIKey |
DTYWJKSSUANMHD-UHFFFAOYSA-N
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| CAS Number |
CAS 377727-87-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15106643, 22523077, 39757057, 78384360, 85227204, 99431560, 103547747, 104082355, 124490457, 134224280, 134339413, 135252259, 137124823, 140294784, 160836615, 162223399, 163097753, 163398980, 163620723, 163686038, 163844940, 164210494, 164764522, 178102248, 185998819, 189659584, 198945905, 204409228, 223396873, 223621321, 228928214, 242062249, 245100517, 249833923, 250177602, 251971425, 252055943, 252485805
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Antagonist | [2] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Parkinson's disease | ||||
| Alcoholism | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Reactome | NGF-independant TRKA activation | |||
| Adenosine P1 receptors | ||||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5614). | |||
| REF 2 | Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. | |||
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