Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07OQF
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| Former ID |
DIB019515
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| Drug Name |
PMID25489658C4d
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| Synonyms |
GTPL8483
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
 |
Download2D MOL
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| Formula |
C17H10BrClO4
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| Canonical SMILES |
C1=CC(=CC(=C1)Cl)OC(=O)C2=CC3=C(C=CC(=C3)CBr)OC2=O
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| InChI |
1S/C17H10BrClO4/c18-9-10-4-5-15-11(6-10)7-14(17(21)23-15)16(20)22-13-3-1-2-12(19)8-13/h1-8H,9H2
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| InChIKey |
RNWNTBMGGUARMR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kallikrein-14 (KLK14) | Target Info | Inhibitor | [2] |
| Kallikrein-5 (KLK5) | Target Info | Inhibitor | [2] | |
| Kallikrein-7 (KLK7) | Target Info | Inhibitor | [2] | |
| Suppressor of tumorigenicity 14 protein (ST14) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | MicroRNAs in cancer | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Reactome | Degradation of the extracellular matrix | |||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet. 2000 Jun;25(2):141-2. | |||
| REF 2 | Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612. | |||
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