Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07MWY
|
|||
| Former ID |
DIB003899
|
|||
| Drug Name |
XR-1853
|
|||
| Synonyms |
XR 1853; XR-1853; AC1O5RT5; 3-((4-(2-(Dimethylamino)ethoxy)phenyl)methylene)-6-(phenylmethylene)-2,5-piperazinedione; 158944-02-6
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Terminated | [1] | |
| Company |
Xenova Ltd
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C22H23N3O3
|
|||
| Canonical SMILES |
CN(C)CCOC1=CC=C(C=C1)C=C2C(=O)NC(=CC3=CC=CC=C3)C(=O)N2
|
|||
| InChI |
1S/C22H23N3O3/c1-25(2)12-13-28-18-10-8-17(9-11-18)15-20-22(27)23-19(21(26)24-20)14-16-6-4-3-5-7-16/h3-11,14-15H,12-13H2,1-2H3,(H,23,27)(H,24,26)/b19-14+,20-15-
|
|||
| InChIKey |
SKAOOZAHHYQXKN-WOBBTWAASA-N
|
|||
| CAS Number |
CAS 158944-02-6
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasminogen activator inhibitor (PAI) | Target Info | Modulator | [2] |
| KEGG Pathway | HIF-1 signaling pathway | |||
| p53 signaling pathway | ||||
| Hippo signaling pathway | ||||
| Complement and coagulation cascades | ||||
| Chagas disease (American trypanosomiasis) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006899) | |||
| REF 2 | Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost. 2002 Jul;88(1):137-43. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.