Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07JLM
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| Former ID |
DIB007569
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| Drug Name |
Alagebrium chloride
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| Synonyms |
PTB; Tetrazolium chloride; ALT-711; ALT-766; N-phenacylthiazolium bromide; Advanced glycosylation end product (AGE)breakers, Alteon; Advanced glycosylation end product (AGE) breakers, Synvista
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| Drug Type |
Small molecular drug
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| Indication | Hypotension [ICD-11: BA20-BA21] | Phase 2/3 | [1] | |
| Company |
Synvista Therapeutics Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H14ClNOS
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| Canonical SMILES |
CC1=C(SC=[N+]1CC(=O)C2=CC=CC=C2)C.[Cl-]
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| InChI |
1S/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1
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| InChIKey |
MKOMESMZHZNBIZ-UHFFFAOYSA-M
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| CAS Number |
CAS 341028-37-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Advanced glycosylation end product receptor (AGER) | Target Info | Breaker | [2], [3] |
| Pathway Interaction Database | amb2 Integrin signaling | |||
| Reactome | RIP-mediated NFkB activation via ZBP1 | |||
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | ||||
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | ||||
| Advanced glycosylation endproduct receptor signaling | ||||
| TRAF6 mediated NF-kB activation | ||||
| WikiPathways | NRF2 pathway | |||
| Nuclear Receptors Meta-Pathway | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | ||||
| AGE/RAGE pathway | ||||
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||||
| Advanced glycosylation endproduct receptor signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01417663) Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function. U.S. National Institutes of Health. | |||
| REF 2 | Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58. | |||
| REF 3 | Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Diabetes. 2012 Aug;61(8):2105-13. | |||
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