Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07JBE
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| Former ID |
DIB015306
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| Drug Name |
CG-200745
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| Synonyms |
CG-0006; CG-005; HDAC inhibitors (cancer, oral/intravenous), CrystalGenomics; Histone deacetylase inhibitors (cancer, oral/intravenous), CrystalGenomics
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Company |
CrystalGenomics Inc
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| Structure |
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Download2D MOL |
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| Formula |
C24H33N3O4
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| Canonical SMILES |
CN(C)CCCNC(=O)C(=CCCCCC(=O)NO)COC1=CC=CC2=CC=CC=C21
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| InChI |
1S/C24H33N3O4/c1-27(2)17-9-16-25-24(29)20(11-4-3-5-15-23(28)26-30)18-31-22-14-8-12-19-10-6-7-13-21(19)22/h6-8,10-14,30H,3-5,9,15-18H2,1-2H3,(H,25,29)(H,26,28)/b20-11+
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| InChIKey |
AUGCSOFQTDKPSO-RGVLZGJSSA-N
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| CAS Number |
CAS 936221-33-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histone deacetylase (HDAC) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01226407) Examine Maximum Tolerated Dose and Pharmacokinetic and Pharmacodynamic Profile. U.S. National Institutes of Health. | |||
| REF 2 | Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells. PLoS One. 2015 Mar 17;10(3):e0119379. | |||
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