Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07IZR
|
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| Former ID |
DNC000197
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| Drug Name |
AMG-126737
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
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| Formula |
C33H38N6O6S2
|
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| Canonical SMILES |
C1=CC(=CC(=C1)S(=O)(=O)NCC2=CC=C(C=C2)OCCCCCOC3=CC=C(C=C3)CNS(=O)(=O)C4=CC=CC(=C4)C(=N)N)C(=N)N
|
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| InChI |
1S/C33H38N6O6S2/c34-32(35)26-6-4-8-30(20-26)46(40,41)38-22-24-10-14-28(15-11-24)44-18-2-1-3-19-45-29-16-12-25(13-17-29)23-39-47(42,43)31-9-5-7-27(21-31)33(36)37/h4-17,20-21,38-39H,1-3,18-19,22-23H2,(H3,34,35)(H3,36,37)
|
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| InChIKey |
CTLMBCYIAXNYOG-UHFFFAOYSA-N
|
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| CAS Number |
CAS 224054-76-6
|
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tryptase alpha/beta-1 (Tryptase) | Target Info | Inhibitor | [1] |
| Reactome | Activation of Matrix Metalloproteinases | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000. | |||
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