Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07GUB
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| Former ID |
DIB019762
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| Drug Name |
DL-TBOA
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| Synonyms |
dl-threo-beta-benzyloxyaspartate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C11H13NO5
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| Canonical SMILES |
C1=CC=C(C=C1)COC(C(C(=O)O)N)C(=O)O
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| InChI |
1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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| InChIKey |
BYOBCYXURWDEDS-IUCAKERBSA-N
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| CAS Number |
CAS 208706-75-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Excitatory amino acid transporter 1 (SLC1A3) | Target Info | Inhibitor | [2] |
| Excitatory amino acid transporter 2 (SLC1A2) | Target Info | Inhibitor | [2] | |
| Excitatory amino acid transporter 3 (SLC1A1) | Target Info | Inhibitor | [3] | |
| Excitatory amino acid transporter 4 (SLC1A6) | Target Info | Inhibitor | [4] | |
| Excitatory amino acid transporter 5 (SLC1A7) | Target Info | Inhibitor | [4] | |
| Panther Pathway | Ionotropic glutamate receptor pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| WikiPathways | Amyotrophic lateral sclerosis (ALS) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4631). | |||
| REF 2 | DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol. 1998 Feb;53(2):195-201. | |||
| REF 3 | Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10. | |||
| REF 4 | Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J Neurochem. 2001 Oct;79(2):297-302. | |||
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