Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07EBF
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| Former ID |
DNCL001597
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| Drug Name |
CK-2017357
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| Synonyms |
Tirasemtiv; 1005491-05-3; Tirasemtiv(CK-2017357); CK-2017357; UNII-G8WSM7R635; G8WSM7R635; 5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one; CK 2017357; 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol; 2H-Imidazo[4,5-b]pyrazin-2-one, 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-;2H-Imidazo[4,5-b]pyrazin-2-one, 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-; Tirasemtiv [USAN:INN]; Tirasemtiv (USAN/INN); SCHEMBL976988; GTPL8280; tiraseMtiv (CK-2017357); CHEMBL3039529; EX-A367; DTXSID90143379; RSQGZEAXODVTOL-UHFFFAOYSA-N
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| Drug Type |
Small molecular drug
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| Indication | Amyotrophic lateral sclerosis [ICD-11: 8B60.0] | Phase 3 | [1] | |
| Muscle fatigue [ICD-11: FB32.5; ICD-10: M62.6; ICD-9: 780.7] | Phase 2 | [2], [3] | ||
| Company |
Cytokinetics
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| Structure |
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Download2D MOL |
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| Formula |
C12H14N4O
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| Canonical SMILES |
CCC(CC)N1C2=NC(=CN=C2NC1=O)C#C
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| InChI |
1S/C12H14N4O/c1-4-8-7-13-10-11(14-8)16(12(17)15-10)9(5-2)6-3/h1,7,9H,5-6H2,2-3H3,(H,13,15,17)
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| InChIKey |
RSQGZEAXODVTOL-UHFFFAOYSA-N
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| CAS Number |
CAS 1005491-05-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fast skeletal muscle troponin complex (TNNC2) | Target Info | Modulator | [4], [5] |
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Striated Muscle Contraction | |||
| WikiPathways | Striated Muscle Contraction | |||
| Muscle contraction | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8280). | |||
| REF 3 | ClinicalTrials.gov (NCT01131013) A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication. U.S. National Institutes of Health. | |||
| REF 4 | Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. | |||
| REF 5 | Effect of tirasemtiv, a selective activator of the fast skeletal muscle troponin complex, in patients with peripheral artery disease. Vasc Med. 2014 May 28;19(4):297-306. | |||
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