Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07CAQ
|
|||
| Former ID |
DIB001396
|
|||
| Drug Name |
SAFINGOL
|
|||
| Synonyms |
Kynac; Kynacyte; SPC-100270; Safingol < Rec INN; L-threo-Dihydrosphingosine; SPC-100271 (HCl); (2S,3S)-2-Aminooctadecane-1,3-diol
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Psoriasis vulgaris [ICD-11: EA90; ICD-9: 696] | Phase 1 | [1], [2] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C18H39NO2
|
|||
| Canonical SMILES |
CCCCCCCCCCCCCCCC(C(CO)N)O
|
|||
| InChI |
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18-/m0/s1
|
|||
| InChIKey |
OTKJDMGTUTTYMP-ROUUACIJSA-N
|
|||
| CAS Number |
CAS 15639-50-6
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein kinase C (PRKC) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00084812) Safingol and Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health. | |||
| REF 2 | A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clin Cancer Res. 2011 Apr 15;17(8):2484-92. | |||
| REF 3 | The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. Int J Oncol. 2009 Dec;35(6):1463-71. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.