Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07BTU
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| Former ID |
DNC004315
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| Drug Name |
6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine
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| Synonyms |
CHEMBL121479; 127116-64-7; 2,4-Pyrimidinediamine, 5-nitro-6-(phenylmethoxy)-; ACMC-20msby; 6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine; SCHEMBL3309544; CTK0F6457; DTXSID40431990; VLVHHGNPHBVEIG-UHFFFAOYSA-N; BDBM50062813; AKOS030620964; 6-Benzyloxy-5-nitropyrimidine-2,4-diamine; 2,4-Diamino-6-benzyloxy-5-nitropyrimidine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H11N5O3
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| Canonical SMILES |
C1=CC=C(C=C1)COC2=NC(=NC(=C2[N+](=O)[O-])N)N
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| InChI |
1S/C11H11N5O3/c12-9-8(16(17)18)10(15-11(13)14-9)19-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,12,13,14,15)
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| InChIKey |
VLVHHGNPHBVEIG-UHFFFAOYSA-N
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| CAS Number |
CAS 127116-64-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | O-6-methylguanine-DNA-alkyltransferase (MGMT) | Target Info | Inhibitor | [1] |
| WikiPathways | DNA Damage Reversal | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8. | |||
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