Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07BSE
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| Former ID |
DNAP001518
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| Drug Name |
Hyaluronate sodium
|
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| Drug Type |
Small molecular drug
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| Indication | Joint lubricant [ICD-11: FA30-FA38] | Approved | [1] | |
| Enthesopathy [ICD-11: FB53-FB55; ICD-10: M77.9; ICD-9: 726] | Phase 3 | [2] | ||
| Pancytopenia [ICD-11: 3A70.Z] | Investigative | [3] | ||
| Structure |
 |
Download2D MOL |
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| Formula |
C28H44N2NaO23+
|
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| Canonical SMILES |
CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]
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| InChI |
1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
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| InChIKey |
YWIVKILSMZOHHF-QJZPQSOGSA-N
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| CAS Number |
CAS 9067-32-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| SuperDrug ATC ID |
D03AX05; M09AX01; R01AX09; S01KA01
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hyaluronic acid receptor (LYVE1) | Target Info | Modulator | [4] |
| Reactome | Hyaluronan uptake and degradation | |||
| WikiPathways | Glycosaminoglycan metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Clinical pipeline report, company report or official report of Genentech. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4954). | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4954). | |||
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