Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07BKR
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| Former ID |
DNCL002295
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| Drug Name |
ARQ 621
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| Synonyms |
ARQ 621; 1095253-39-6; ARQ-621; UNII-UU55190C8S; ARQ621; UU55190C8S; (R)-N-(3-AMINOPROPYL)-3-CHLORO-N-(1-(7-CHLORO-4-OXO-3-(PHENYLAMINO)-3,4-DIHYDROQUINAZOLIN-2-YL)BUT-3-YN-1-YL)-2-FLUOROBENZAMIDE; Benzamide, N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluoro-; SCHEMBL361201; C28H24Cl2FN5O2; DTXSID80148974; EX-A857; UPJSUQWHUVLLNW-XMMPIXPASA-N; MolPort-035-789-699; BCP28395; 2122AH; ZINC68203755; s7355; AKOS032945139; SB19448; NCGC00386362-01; KB-74734
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| Drug Type |
Small molecular drug
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| Indication | Haematological malignancy [ICD-11: 2B33.Y] | Phase 1 | [1] | |
| Company |
ArQule
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| Structure |
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Download2D MOL |
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| Formula |
C28H24Cl2FN5O2
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| Canonical SMILES |
C#CCC(C1=NC2=C(C=CC(=C2)Cl)C(=O)N1NC3=CC=CC=C3)N(CCCN)C(=O)C4=C(C(=CC=C4)Cl)F
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| InChI |
1S/C28H24Cl2FN5O2/c1-2-8-24(35(16-7-15-32)27(37)21-11-6-12-22(30)25(21)31)26-33-23-17-18(29)13-14-20(23)28(38)36(26)34-19-9-4-3-5-10-19/h1,3-6,9-14,17,24,34H,7-8,15-16,32H2/t24-/m1/s1
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| InChIKey |
UPJSUQWHUVLLNW-XMMPIXPASA-N
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| CAS Number |
CAS 1095253-39-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kinesin-like protein KIF11 (KIF11) | Target Info | Modulator | [2] |
| Reactome | MHC class II antigen presentation | |||
| Kinesins | ||||
| WikiPathways | MHC class II antigen presentation | |||
| Kinesins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00825487) Dose Escalation Study of ARQ 621 in Adult Patients With Metastatic Solid Tumors and Hematologic Malignancies. U.S. National Institutes of Health. | |||
| REF 2 | Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. | |||
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