Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07ADU
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| Former ID |
DIB006228
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| Drug Name |
AEM-28
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| Synonyms |
Apo-E peptide mimetic (acute coronary syndrome), University of Alabama at Birmingham/LipimetiX
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| Indication | Familial hypercholesterolemia [ICD-11: 5C80.00; ICD-10: E78.0] | Phase 2 | [1] | |
| Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Phase 1/2 | [2] | ||
| Company |
Lipimetix development
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Apolipoprotein E (APOE) | Target Info | Modulator | [3] |
| KEGG Pathway | Alzheimer's disease | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| FSH Signaling Pathway | ||||
| Wnt Signaling Pathway | ||||
| Reactome | Chylomicron-mediated lipid transport | |||
| HDL-mediated lipid transport | ||||
| Scavenging by Class A Receptors | ||||
| Retinoid metabolism and transport | ||||
| WikiPathways | Statin Pathway | |||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Binding and Uptake of Ligands by Scavenger Receptors | ||||
| Visual phototransduction | ||||
| Lipid digestion, mobilization, and transport | ||||
| Alzheimers Disease | ||||
| Vitamin B12 Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | ClinicalTrials.gov (NCT02100839) Safety Study of AEM-28 to Treat Refractory Hypercholesterolemia. U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of LipimetiX. | |||
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