Drug Information
Drug General Information | Top | |||
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Drug ID |
D06ZZM
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Former ID |
DNC008763
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Drug Name |
3-chloro-4-(o-tolyloxy)benzonitrile
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Synonyms |
CHEMBL490955; 3-chloro-4-(o-tolyloxy)benzonitrile; SCHEMBL4168825; BDBM50248505
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C14H10ClNO
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Canonical SMILES |
CC1=CC=CC=C1OC2=C(C=C(C=C2)C#N)Cl
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InChI |
1S/C14H10ClNO/c1-10-4-2-3-5-13(10)17-14-7-6-11(9-16)8-12(14)15/h2-8H,1H3
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InChIKey |
LMZHFUQMQDTSFO-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Androgen receptor messenger RNA (AR mRNA) | Target Info | Inhibitor | [1] |
KEGG Pathway | Oocyte meiosis | |||
Pathways in cancer | ||||
Prostate cancer | ||||
NetPath Pathway | EGFR1 Signaling Pathway | |||
AndrogenReceptor Signaling Pathway | ||||
FSH Signaling Pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Coregulation of Androgen receptor activity | ||||
Regulation of Androgen receptor activity | ||||
Nongenotropic Androgen signaling | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
FOXA1 transcription factor network | ||||
Notch-mediated HES/HEY network | ||||
Reactome | Nuclear Receptor transcription pathway | |||
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Integrated Pancreatic Cancer Pathway | ||||
Prostate Cancer | ||||
Integrated Breast Cancer Pathway | ||||
Nuclear Receptors | ||||
Androgen receptor signaling pathway |
References | Top | |||
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REF 1 | Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. |
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