Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06YHL
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| Former ID |
DAP000448
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| Drug Name |
Cefamandole
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| Synonyms |
Cefadole; Cefamandolum; Cefamandole (USAN/INN); (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic acid; (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}ceph-3-em-4-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Microorganisms infection [ICD-11: 1A00-1A09; ICD-10: A00-B99] | Approved | [1] | |
| Therapeutic Class |
Antibiotics
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| Company |
Eli Lilly
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H18N6O5S2
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| Canonical SMILES |
CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(C4=CC=CC=C4)O)SC2)C(=O)O
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| InChI |
1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1
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| InChIKey |
OLVCFLKTBJRLHI-AXAPSJFSSA-N
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| CAS Number |
CAS 34444-01-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9096, 602882, 7849403, 7978872, 10302112, 11466775, 11467895, 11486409, 14833916, 15331577, 46508882, 47349540, 47795225, 48019109, 48318624, 48415710, 57405452, 77400779, 81044354, 85788971, 87322628, 92719034, 93575875, 103023094, 103331360, 104133790, 109719094, 124766405, 126621136, 126657633, 134223450, 134337744, 134999140, 135883952, 136357154, 137003418, 142043553, 160964623, 175268221, 175442895, 179150349, 184546701, 223668260, 226423119, 250133947, 252347133
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| ChEBI ID |
CHEBI:3480
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| SuperDrug ATC ID |
J01DC03
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| SuperDrug CAS ID |
cas=034444014
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Binder | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | The impact of penicillinase on cefamandole treatment and prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 1998 Jan;177(1):146-54. | |||
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