Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06YFA
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| Former ID |
DAP000282
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| Drug Name |
Bromocriptine
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| Synonyms |
Bagren; Bromergocryptine; Bromocriptin; Bromocriptina; Bromocriptinum; Bromocryptin; Bromocryptine; Bromoergocriptine; Bromoergocryptine; Ergoset; Parlodel; Bromocriptine [BAN]; Bromocriptine methanesulfonate; Parlodel Snaptabs; Alti-Bromocriptine; Apo-Bromocriptine; Bromocriptina [INN-Spanish]; Bromocriptinum [INN-Latin]; CB-154; Parlodel (TN); Bromocriptine (USAN/INN); Bromocriptine [USAN:BAN:INN]; Ergocryptine, 2-bromo-(8CI); (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman; (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione; (5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman; (5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman; (6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide; 2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-alpha-(2-methylpropyl)ergotamin-3',6',18-trione; 2-Bromo-alpha-ergocryptine; 2-Bromo-alpha-ergokryptin; 2-Bromo-alpha-ergokryptine; 2-Bromoergocryptine Methanesulfonate; 2-Bromoergokryptine
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Approved | [1], [2] | |
| Therapeutic Class |
Antiparkinson Agents
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| Company |
Norvatis Phamaceuticals Corporation
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| Structure |
 |
Download2D MOL |
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| Formula |
C32H40BrN5O5
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| Canonical SMILES |
CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O
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| InChI |
1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1
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| InChIKey |
OZVBMTJYIDMWIL-AYFBDAFISA-N
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| CAS Number |
CAS 25614-03-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9074, 605475, 7978821, 8171939, 11405760, 11466149, 11467269, 11485837, 14765834, 14765835, 17397319, 24262982, 34673282, 46505504, 47217056, 47440541, 47589227, 47589228, 47885652, 48415647, 49658626, 49965589, 50872033, 53789332, 57311062, 85788755, 90340796, 92712670, 93166622, 103170197, 103936294, 104309997, 117390441, 124749509, 124886913, 126625420, 126656565, 127298886, 127298887, 127298888, 127298889, 127298890, 127298891, 127298892, 127298893, 127298894, 127298895, 127298896, 127298897, 127298898
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| ChEBI ID |
CHEBI:3181
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| ADReCS Drug ID | BADD_D00304 ; BADD_D00305 | |||
| SuperDrug ATC ID |
G02CB01; N04BC01
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| SuperDrug CAS ID |
cas=025614033
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -1.548; p = 0.012). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -1.02; p = 0.007). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.921; p = 0.003). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -1.348; p = 0.006). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -1.164; p = 0.011). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -0.993; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -1.099; p = 0.015). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.795; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -1.097; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.699; p = 0.015). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.895; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -1.066; p = 0.007). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -1.016; p = 0.004). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.519; p = 0.05). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.512; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.707; p = 0.05). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.576; p = 0.045). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -1.361; p = 0.017). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -1.211; p = 0.003). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -1.343; p = 0.002). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Odoribacter splanchnicus (log2FC = -0.976; p = 0.021). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -1.364; p = 0.009). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.841; p = 0.013). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.569; p = 0.016). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Pretovella copri DSM 18205 (log2FC = -1.272; p = 0.024). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -1.012; p = 0.031). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -1.023; p = 0.017). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -0.897; p = 0.003). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bifidobacterium ruminantium (log2FC = -0.887; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -0.826; p = 0.038). | |||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -0.789; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -1.157; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -0.622; p = 0.031). | |||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -0.963; p = 0.019). | |||
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Studied Microbe: Escherichia coli BW25113
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Escherichia coli BW25113 (log2FC = -1.242; p = 0.001). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Proteus penneri ATCC 35198 (log2FC = -0.714; p = 0.025). | |||
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Studied Microbe: Providencia rettgeri DSM 1131
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -0.731; p = 0.041). | |||
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Studied Microbe: Providencia stuartii ATCC 25827
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -0.784; p = 0.006). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Salmonella typhimurium LT2 (log2FC = -0.622; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -0.889; p = 0.007). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -0.699; p = 0.031). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Anaerostipes sp. (log2FC = -0.574; p = 0.05). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -1.327; p = 0.001). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -1.13; p = 0.016). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Blautia hansenii DSM20583 (log2FC = -1.789; p = 0.0). | |||
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Studied Microbe: Blautia luti DSM 14534
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Blautia luti DSM 14534 (log2FC = -0.647; p = 0.006). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -1.081; p = 0.028). | |||
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Studied Microbe: Clostridium difficile 120
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium difficile 120 (log2FC = -1.563; p = 0.002). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -0.958; p = 0.004). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium sp. (log2FC = -1.977; p = 0.0). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -1.102; p = 0.01). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -0.717; p = 0.017). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -0.641; p = 0.046). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -1.321; p = 0.008). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Eubacterium hallii DSM3353 (log2FC = -0.773; p = 0.019). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -0.925; p = 0.03). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -0.64; p = 0.05). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Roseburia intestinalis L1-82 (log2FC = -1.022; p = 0.028). | |||
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Studied Microbe: Ruminococcus gnavus ATCC 29149
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -0.865; p = 0.03). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -0.73; p = 0.012). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -0.911; p = 0.02). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -1.718; p = 0.014). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -0.933; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -0.617; p = 0.031). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -1.127; p = 0.0). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bromocriptine mesylate can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -1.198; p = 0.013). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 35). | |||
| REF 2 | Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Silymarin BIO-C, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats. Phytomedicine. 2009 Sep;16(9):839-44. | |||
| REF 5 | Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration. J Neurosci. 2009 Feb 4;29(5):1538-43. | |||
| REF 6 | The behavioral toxicity of bromocriptine in patients with psychiatric illness. J Clin Psychopharmacol. 1989 Dec;9(6):417-22. | |||
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