Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06XZR
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| Former ID |
DIB011837
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| Drug Name |
Pizotyline
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| Synonyms |
Pizotifen; PIZOTYLINE; 15574-96-6; Sandomigran; Litec; Sandomygran; Pizotifenum; Pizotifeno; Polomigran; Pizotifene; BC-105; BC 105; Pizotyline [USAN]; Pizotifan; Pizotifene [INN-French]; Pizotifenum [INN-Latin]; Pizotifeno [INN-Spanish]; UNII-0BY8440V3N; EINECS 239-632-9; BRN 0753534; C19H21NS; CHEBI:50212; FIADGNVRKBPQEU-UHFFFAOYSA-N; Pizotifen (INN); Pizotifen [INN]; 0BY8440V3N; Pizotyline (USAN); 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
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| Drug Type |
Small molecular drug
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| Indication | Headache [ICD-11: 8A80-8A84] | Approved | [1], [2] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C19H21NS
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| Canonical SMILES |
CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1
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| InChI |
1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3
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| InChIKey |
FIADGNVRKBPQEU-UHFFFAOYSA-N
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| CAS Number |
CAS 15574-96-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5010370, 7980344, 8169757, 10509182, 14751522, 24714723, 25623658, 26756535, 34669927, 47207192, 47291792, 47365864, 47662958, 48035805, 48185659, 48416449, 49699409, 50015996, 57310432, 75504446, 85209443, 85278783, 85787805, 85788911, 89503750, 92711291, 103223858, 104299887, 117404128, 118048642, 124892409, 124892410, 125324589, 125536630, 126631018, 126657449, 126667030, 127850175, 131342662, 131895591, 134224322, 134993421, 135650835, 135668219, 137009871, 142472728, 144205577, 162177650, 162224663, 163137347
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| ChEBI ID |
CHEBI:50212
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| ADReCS Drug ID | BADD_D01787 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides uniformis
Show/Hide Hierarchy
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Pizotifen malate (adjusted p-values: 1.12E-04). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT receptor (5HTR) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 93). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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