Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06WBA
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| Former ID |
DIB001588
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| Drug Name |
SQ-28603
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| Synonyms |
CHEMBL196902; beta-Alanine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-; 100845-83-8; AC1L3X7M; SCHEMBL389731; 3-[(2-benzyl-3-sulfanylpropanoyl)amino]propanoic acid; ZCTDTVUDURCGFX-UHFFFAOYSA-N; HY-U00171; BDBM50175499; CS-7234; LS-186925; LS-187575; 3-(2-Benzyl-3-mercapto-propionylamino)-propionic acid; (+/-)-3-[[2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]amino]propanoic acid
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
| Company |
Squibb Corp
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H17NO3S
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| Canonical SMILES |
C1=CC=C(C=C1)CC(CS)C(=O)NCCC(=O)O
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| InChI |
1S/C13H17NO3S/c15-12(16)6-7-14-13(17)11(9-18)8-10-4-2-1-3-5-10/h1-5,11,18H,6-9H2,(H,14,17)(H,15,16)
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| InChIKey |
ZCTDTVUDURCGFX-UHFFFAOYSA-N
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| CAS Number |
CAS 100845-83-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutral endopeptidase (MME) | Target Info | Modulator | [2] |
| KEGG Pathway | Renin-angiotensin system | |||
| Hematopoietic cell lineage | ||||
| Protein digestion and absorption | ||||
| Alzheimer's disease | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | Metabolism of Angiotensinogen to Angiotensins | |||
| Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Alzheimers Disease | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000347) | |||
| REF 2 | Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys. Can J Physiol Pharmacol. 1991 Oct;69(10):1609-17. | |||
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