Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06VBQ
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| Former ID |
DNC010550
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| Drug Name |
GSK-0660
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| Synonyms |
GSK0660; 1014691-61-2; GSK 0660; GSK-0660; CHEMBL592652; 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester; methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate; C19H18N2O5S2; methyl 3-(N-(2-methoxy-4-(phenylamino)phenyl)sulfamoyl)thiophene-2-carboxylate; 3-(((2-Methoxy-4-(phenylamino)phenyl)amino]sulfonyl)-2-thiophenecarboxylic acid methyl ester; 3-[[[2-METHOXY-4-(PHENYLAMINO)PHENYL]AMINO]SULFONYL]-2-THIOPHENECARBOXYLIC ACID METHYL ESTER
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H18N2O5S2
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| Canonical SMILES |
COC1=C(C=CC(=C1)NC2=CC=CC=C2)NS(=O)(=O)C3=C(SC=C3)C(=O)OC
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| InChI |
1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3
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| InChIKey |
NDFKBGWLUHKMFY-UHFFFAOYSA-N
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| CAS Number |
CAS 1014691-61-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:94813
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Peroxisome proliferator-activated receptor delta (PPARD) | Target Info | Inhibitor | [2] |
| KEGG Pathway | PPAR signaling pathway | |||
| Wnt signaling pathway | ||||
| Pathways in cancer | ||||
| Acute myeloid leukemia | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Wnt signaling pathway | |||
| Pathway Interaction Database | Presenilin action in Notch and Wnt signaling | |||
| RXR and RAR heterodimerization with other nuclear receptor | ||||
| Reactome | Import of palmitoyl-CoA into the mitochondrial matrix | |||
| Regulation of pyruvate dehydrogenase (PDH) complex | ||||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Wnt Signaling Pathway and Pluripotency | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Vitamin D Receptor Pathway | ||||
| Ectoderm Differentiation | ||||
| Adipogenesis | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3441). | |||
| REF 2 | Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversibl... J Med Chem. 2010 Feb 25;53(4):1857-61. | |||
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