Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06UVO
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| Former ID |
DIB014433
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| Drug Name |
DuP-654
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| Synonyms |
DUP-654; 2-benzylnaphthalen-1-ol; 2-Benzyl-1-naphthol; Dup 654; 36441-32-4; DuP654; 2-(phenylmethyl)-1-naphthol; UNII-96251IH9OJ; 2-Benzyl-1-hydroxynaphthalene; 2-(Phenylmethyl)-1-naphthalenol; BRN 1965326; CHEMBL85000; 96251IH9OJ; 1-Naphthalenol, 2-(phenylmethyl)-; AC1L4NCB; AC1Q7AVK; 2-phenylmethyl1-naphthol; 2-phenylmethyl-1-naphthol; 2-Benzyl-naphthalen-1-ol; 4-06-00-04990 (Beilstein Handbook Reference); SCHEMBL664782; DTXSID00189965; CZTSOXCSVFEFIK-UHFFFAOYSA-N; ZINC1485058; BDBM50004679; 2-Benzyl-naphthalen-1-ol(DuP 654)
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| Drug Type |
Small molecular drug
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| Indication | Pruritus [ICD-11: EC90; ICD-10: L29, L29.9; ICD-9: 698] | Discontinued in Phase 2 | [1] | |
| Company |
Bristol-Myers Squibb Pharma Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H14O
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| Canonical SMILES |
C1=CC=C(C=C1)CC2=C(C3=CC=CC=C3C=C2)O
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| InChI |
1S/C17H14O/c18-17-15(12-13-6-2-1-3-7-13)11-10-14-8-4-5-9-16(14)17/h1-11,18H,12H2
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| InChIKey |
CZTSOXCSVFEFIK-UHFFFAOYSA-N
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| CAS Number |
CAS 36441-32-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 5-lipoxygenase (5-LOX) | Target Info | Inhibitor | [2] |
| BioCyc | Aspirin-triggered lipoxin biosynthesis | |||
| Resolvin D biosynthesis | ||||
| Leukotriene biosynthesis | ||||
| Lipoxin biosynthesis | ||||
| Aspirin triggered resolvin D biosynthesis | ||||
| Aspirin triggered resolvin E biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Ovarian steroidogenesis | ||||
| Toxoplasmosis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003690) | |||
| REF 2 | The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II. Skin Pharmacol. 1993;6(2):148-51. | |||
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