Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06UNX
|
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| Former ID |
DNC002716
|
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| Drug Name |
Verdoheme
|
|||
| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C30H29FeN4O3+3
|
|||
| Canonical SMILES |
CC1=C(C2=[O+]C3=NC(=CC4=C(C(=C([N-]4)C=CN=C(C=C1[N-]2)C(=C)C)CCC(=O)O)C)C(=C3C)C=C)C=C.[Fe+4]
|
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| InChI |
1S/C30H30N4O3.Fe/c1-8-20-19(7)29-34-27(20)15-25-18(6)22(10-11-28(35)36)23(32-25)12-13-31-24(16(3)4)14-26-17(5)21(9-2)30(33-26)37-29;/h8-9,12-15H,1-3,10-11H2,4-7H3,(H2-,31,32,33,34,35,36);/q;+4/p-1
|
|||
| InChIKey |
QNHRNHLUNLNYAK-UHFFFAOYSA-M
|
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Heme oxygenase 1 (HMOX1) | Target Info | Inhibitor | [1] |
| BioCyc | Heme degradation | |||
| KEGG Pathway | Porphyrin and chlorophyll metabolism | |||
| HIF-1 signaling pathway | ||||
| Mineral absorption | ||||
| MicroRNAs in cancer | ||||
| Pathwhiz Pathway | Porphyrin Metabolism | |||
| Pathway Interaction Database | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | |||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Iron uptake and transport | |||
| WikiPathways | Oxidative Stress | |||
| Transcriptional activation by NRF2 | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| miR-targeted genes in squamous cell - TarBase | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in leukocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. | |||
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