Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06TKE
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| Former ID |
DIB008607
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| Drug Name |
ZD-7288
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| Synonyms |
N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine; AC1L3XOD; SCHEMBL9380740; GTPL2359; ZINC100058922; N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine; AKOS027381051; ZINC255004003
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD-11: BA40; ICD-9: 413] | Phase 2 | [1], [2] | |
| Company |
Zeneca Group plc
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| Structure |
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Download2D MOL
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| Formula |
C15H21ClN4
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| Canonical SMILES |
CCN(C1=CC=CC=C1)C2=CC(=[N+](C(=N2)C)C)NC.[Cl-]
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| InChI |
1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
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| InChIKey |
DUWKUHWHTPRMAP-UHFFFAOYSA-N
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| CAS Number |
CAS 133059-99-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hyperpolarization cyclic nucleotide-gated channel (HCN) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2359). | |||
| REF 2 | ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. World J Gastroenterol. 2014 Feb 28;20(8):2091-7. | |||
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