Drug Information
Drug General Information | Top | |||
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Drug ID |
D06TGR
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Former ID |
DNC005959
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Drug Name |
8-(3-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one
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Synonyms |
CHEMBL200685; 8-(3-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one; SCHEMBL5258643; WPUKKEMHTVGTFK-UHFFFAOYSA-N; BDBM50178081
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H17NO4
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Canonical SMILES |
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC(=CC=C4)O
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InChI |
1S/C19H17NO4/c21-14-4-1-3-13(11-14)15-5-2-6-16-17(22)12-18(24-19(15)16)20-7-9-23-10-8-20/h1-6,11-12,21H,7-10H2
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InChIKey |
WPUKKEMHTVGTFK-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
KEGG Pathway | Non-homologous end-joining | |||
Cell cycle | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
Coregulation of Androgen receptor activity | ||||
Class I PI3K signaling events mediated by Akt | ||||
BARD1 signaling events | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | |||
WikiPathways | DNA Damage Response | |||
Non-homologous end joining | ||||
FAS pathway and Stress induction of HSP regulation | ||||
Cytosolic sensors of pathogen-associated DNA | ||||
Retinoblastoma (RB) in Cancer | ||||
Prostate Cancer | ||||
Double-Strand Break Repair | ||||
Cell Cycle | ||||
miRNA Regulation of DNA Damage Response |
References | Top | |||
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REF 1 | Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. |
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