Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06PYP
|
|||
| Former ID |
DND000030
|
|||
| Drug Name |
JTS-653
|
|||
| Indication | Overactive bladder [ICD-11: GC50.0; ICD-10: N32.8] | Discontinued in Phase 2 | [1] | |
| Pain [ICD-11: MG30-MG3Z] | Discontinued in Phase 2 | [1] | ||
| Company |
Japan Tobacco
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028532) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). | |||
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