Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06OQI
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| Former ID |
DIB015151
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| Drug Name |
Tilarginine acetate
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| Synonyms |
53308-83-1; L-NMMA acetate; UNII-2FL3530AF2; 2FL3530AF2; DSSTox_RID_81122; DSSTox_CID_25780; DSSTox_GSID_45780; SMR000449329; CAS-53308-83-1; N-omega-Monomethyl-L-arginine monoacetate, 99%
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| Drug Type |
Small molecular drug
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| Indication | Myocardial infarction [ICD-11: BA41-BA43; ICD-9: 410] | Phase 3 | [1] | |
| Angina pectoris [ICD-11: BA40; ICD-9: 413] | Discontinued in Phase 2 | [2] | ||
| Company |
ArgiNOx
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H20N4O4
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| Canonical SMILES |
CC(=O)O.CN=C(N)NCCCC(C(=O)O)N
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| InChI |
1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
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| InChIKey |
IKPNWIGTWUZCKM-JEDNCBNOSA-N
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| CAS Number |
CAS 53308-83-1
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00112281) A Study of the Safety and Efficacy of Nitric Oxide Reduction in Patients With Cardiogenic Shock After a Heart Attack. U.S. National Institutes of Health. | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003882) | |||
| REF 3 | Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA. 2007 Apr 18;297(15):1657-66. | |||
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