Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06NYA
|
|||
| Former ID |
DCL000670
|
|||
| Drug Name |
2-Methoxyestradiol
|
|||
| Synonyms |
ESM; Panzem; PulmoLAR; Panzem NCD; M 6383; (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol; (17beta)-2-methoxyestra-1(10),2,4-triene-3,17-diol; (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER; 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether; 2,3,17beta-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether; 2-Hydroxyestradiol 2-methyl ether; 2-Hydroxyestradol 2-methyl ether; 2-ME2, 2-Methoxyestradiol; 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol; 2-Methoxyestradiol-17beta; 3,17beta-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Pulmonary arterial hypertension [ICD-11: BB01.0; ICD-9: 416] | Phase 2 | [1] | |
| Company |
EntreMed
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C19H26O3
|
|||
| Canonical SMILES |
CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O
|
|||
| InChI |
1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
|
|||
| InChIKey |
CQOQDQWUFQDJMK-SSTWWWIQSA-N
|
|||
| CAS Number |
CAS 362-07-2
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
7686, 825710, 841378, 7887359, 8190445, 11532969, 12015344, 14898499, 14923020, 17405300, 17487140, 24278561, 24702257, 43123109, 48185196, 48334733, 49965824, 50473704, 53777845, 53787147, 56312168, 56313815, 56423644, 57288593, 57316122, 71821515, 90340800, 91690349, 92298266, 92304296, 99437043, 103231166, 103956563, 104226314, 104336411, 117616593, 121361504, 124749957, 124757104, 124799546, 124891665, 125163908, 126523247, 127663438, 131480734, 135024732, 136348789, 136367367, 137018345, 141146716
|
|||
| ChEBI ID |
CHEBI:28955
|
|||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | HIF-1-alpha and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats. Neurol Res. 2011 Jul;33(6):583-92. | |||
| REF 2 | 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squam... Clin Cancer Res. 2004 Dec 15;10(24):8665-73. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.