Drug Information
Drug General Information | Top | |||
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Drug ID |
D06NTB
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Former ID |
DNC004168
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Drug Name |
3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole
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Synonyms |
21000-95-3; BRN 0191400; CHEMBL57478; 3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole; INDOLE, 3-((4-METHYLPIPERIDINO)METHYL)-; 3-((4-Methylpiperidino)methyl)indole; 3-[(4-methylpiperidin-1-yl)methyl]-1H-indole; AC1L1JK7; AC1Q2R9P; Oprea1_731728; Oprea1_382776; AURORA 16336; SCHEMBL13504100; CTK8H5660; DTXSID30175210; MolPort-001-815-823; ZINC142608; BDBM50050469; STK617550; 3-[(4-methylpiperidyl)methyl]indole; AKOS002266584; MCULE-4620579742; ACM21000953; 3-(4-Methylpiperidinomethyl)-1H-indole; LS-83280; BAS 02946824; ST50190326
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C15H20N2
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Canonical SMILES |
CC1CCN(CC1)CC2=CNC3=CC=CC=C32
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InChI |
1S/C15H20N2/c1-12-6-8-17(9-7-12)11-13-10-16-15-5-3-2-4-14(13)15/h2-5,10,12,16H,6-9,11H2,1H3
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InChIKey |
DGCGMYNLCDVYMB-UHFFFAOYSA-N
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CAS Number |
CAS 21000-95-3
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Dopamine D2 receptor (D2R) | Target Info | Inhibitor | [1] |
Dopamine D3 receptor (D3R) | Target Info | Inhibitor | [1] | |
Dopamine D4 receptor (D4R) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Dopaminergic synapse | ||||
Rap1 signaling pathway | ||||
cAMP signaling pathway | ||||
Gap junction | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Alcoholism | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Dopamine receptor mediated signaling pathway | ||||
Nicotine pharmacodynamics pathway | ||||
Reactome | Dopamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Hypothetical Network for Drug Addiction | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
Genes and (Common) Pathways Underlying Drug Addiction | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Nicotine Activity on Dopaminergic Neurons | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. |
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