Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06NQH
|
|||
| Former ID |
DNCL002458
|
|||
| Drug Name |
RG7155
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [1] | |
| Company |
Roche
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Colony stimulating factor-1 receptor (CSF-1R) | Target Info | Modulator | [2] |
| Macrophage colony-stimulating factor 1 (CSF1) | Target Info | Antagonist | [3] | |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| Cytokine-cytokine receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Osteoclast differentiation | ||||
| Hematopoietic cell lineage | ||||
| TNF signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | Signaling events mediated by PTP1B | |||
| Signaling events mediated by TCPTP | ||||
| Integrins in angiogenesis | ||||
| WikiPathways | Cytokines and Inflammatory Response | |||
| Hematopoietic Stem Cell Differentiation | ||||
| Differentiation Pathway | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| Folate Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035593) | |||
| REF 2 | Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 2014 Jun 16;25(6):846-59. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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