Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06MBI
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| Former ID |
DIB019089
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| Drug Name |
TG003
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| Synonyms |
Clk inhibitor; TG 003; TG-003
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H15NO2S
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| Canonical SMILES |
CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C
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| InChI |
1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
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| InChIKey |
BGVLELSCIHASRV-QPEQYQDCSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID |
845636, 3896227, 9162503, 10318949, 12577314, 16338860, 17405452, 24278611, 25687204, 26758446, 32753954, 50105027, 50105028, 50105029, 53778000, 57409229, 80848732, 85239700, 87535463, 88957742, 90341206, 99302678, 103567465, 104098218, 105093889, 110756923, 121361514, 124360161, 124750081, 124842363, 124887371, 134597849, 135653343, 162249259, 163564848, 163565291, 163688390, 172919681, 174009343, 178102565, 179235813, 201760346, 204377882, 210275221, 210280860, 223958316, 229036152, 252160432, 252473615
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CDC-like kinase 1 (CLK1) | Target Info | Inhibitor | [2] |
| CDC-like kinase 2 (CLK2) | Target Info | Inhibitor | [2] | |
| Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) | Target Info | Inhibitor | [3] | |
| Target's Patent Info | CDC-like kinase 1 (CLK1) | Target's Patent Info | [2] | |
| CDC-like kinase 2 (CLK2) | Target's Patent Info | [2] | ||
| Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) | Target's Patent Info | [3] | ||
| NetPath Pathway | TCR Signaling Pathway | |||
| EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| WikiPathways | mRNA Processing | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5942). | |||
| REF 2 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. | |||
| REF 3 | Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. | |||
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