Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06KWH
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| Drug Name |
DAB-486-IL-2
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| Synonyms |
153641-26-0
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin 2 receptor beta (IL2RB) | Target Info | Modulator | [1] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Endocytosis | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Measles | ||||
| HTLV-I infection | ||||
| Transcriptional misregulation in cancer | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Interleukin signaling pathway | |||
| Pathway Interaction Database | IL12-mediated signaling events | |||
| SHP2 signaling | ||||
| IL2-mediated signaling events | ||||
| IL2 signaling events mediated by PI3K | ||||
| IL2 signaling events mediated by STAT5 | ||||
| Downstream signaling in naï | ||||
| Reactome | GPVI-mediated activation cascade | |||
| G beta:gamma signalling through PI3Kgamma | ||||
| Interleukin-2 signaling | ||||
| RAF/MAP kinase cascade | ||||
| Interleukin receptor SHC signaling | ||||
| WikiPathways | IL-2 Signaling Pathway | |||
| Inflammatory Response Pathway | ||||
| Interleukin-2 signaling | ||||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Interleukin 2 receptor targeted fusion toxin (DAB486-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice. Eur J Immunol. 1992 Mar;22(3):697-702. | |||
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