Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06HSC
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| Former ID |
DNC007651
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| Drug Name |
Folate gamma-L-phenylalaninehydroxamic acid
|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
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| Formula |
C28H29N9O7
|
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| Canonical SMILES |
C1=CC=C(C=C1)CC(C(=O)NO)NC(=O)CCC(C(=O)O)NC(=O)C2=CC=C(C=C2)NCC3=CN=C4C(=N3)C(=O)NC(=N4)N
|
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| InChI |
1S/C28H29N9O7/c29-28-35-23-22(26(41)36-28)32-18(14-31-23)13-30-17-8-6-16(7-9-17)24(39)34-19(27(42)43)10-11-21(38)33-20(25(40)37-44)12-15-4-2-1-3-5-15/h1-9,14,19-20,30,44H,10-13H2,(H,33,38)(H,34,39)(H,37,40)(H,42,43)(H3,29,31,35,36,41)/t19-,20-/m0/s1
|
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| InChIKey |
WYBGJFMKGROIBY-PMACEKPBSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Matrix metalloproteinase-7 (MMP-7) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Wnt signaling pathway | |||
| NetPath Pathway | Wnt Signaling Pathway | |||
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Wnt signaling pathway | ||||
| CCKR signaling map ST | ||||
| Pathway Interaction Database | Posttranslational regulation of adherens junction stability and dissassembly | |||
| p75(NTR)-mediated signaling | ||||
| Syndecan-1-mediated signaling events | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| WikiPathways | Wnt Signaling Pathway and Pluripotency | |||
| Activation of Matrix Metalloproteinases | ||||
| AGE/RAGE pathway | ||||
| Matrix Metalloproteinases | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. | |||
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