Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06CXU
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| Former ID |
DIB019274
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| Drug Name |
PMID23642479C17
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| Synonyms |
MLS004256654; GTPL8161; KUC107541N; BDBM50435449; KSC-14-92; NCGC00241335-01; SMR003081709
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C18H13Cl2N3O2
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| Canonical SMILES |
C1OC2=C(O1)C=C(C=C2)C3=NC(=NC=C3)NCC4=CC(=CC(=C4)Cl)Cl
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| InChI |
1S/C18H13Cl2N3O2/c19-13-5-11(6-14(20)8-13)9-22-18-21-4-3-15(23-18)12-1-2-16-17(7-12)25-10-24-16/h1-8H,9-10H2,(H,21,22,23)
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| InChIKey |
FFJGYBJUQCZAAY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CDC-like kinase 1 (CLK1) | Target Info | Inhibitor | [1] |
| CDC-like kinase 2 (CLK2) | Target Info | Inhibitor | [1] | |
| CDC-like kinase 4 (CLK4) | Target Info | Inhibitor | [1] | |
| Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) | Target Info | Inhibitor | [1] | |
| Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) | Target Info | Inhibitor | [1] | |
| NetPath Pathway | TCR Signaling Pathway | |||
| EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| WikiPathways | mRNA Processing | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. | |||
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