Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06CSI
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| Former ID |
DNC014829
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| Drug Name |
Alpha,beta-methylene-dTTP
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| Synonyms |
alpha,beta-CH2-DTTP; alpha,beta-methylene-dTTP; alpha,beta-Methylenedeoxythymidine 5'-triphosphate; CHEMBL1162299; 24716-71-0; Thymidine, 5'-O-(1,3,5,5-tetrahydroxy-4-oxa-1,3,5-triphosphapent-1-yl)-, P,P',P''-trioxide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H19N2O13P3
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| Canonical SMILES |
CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(CP(=O)(O)OP(=O)(O)O)O)O
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| InChI |
1S/C11H19N2O13P3/c1-6-3-13(11(16)12-10(6)15)9-2-7(14)8(25-9)4-24-27(17,18)5-28(19,20)26-29(21,22)23/h3,7-9,14H,2,4-5H2,1H3,(H,17,18)(H,19,20)(H,12,15,16)(H2,21,22,23)/t7-,8+,9+/m0/s1
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| InChIKey |
AFUOLHFRDGMFSB-DJLDLDEBSA-N
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| CAS Number |
CAS 24716-71-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability... J Med Chem. 2008 Oct 23;51(20):6460-70. | |||
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