Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06BCB
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| Former ID |
DAP001437
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| Drug Name |
Vinpocetine
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| Synonyms |
Bravinton; Cavinton; Ceractin; Vinpocetinum; Apovincaminic acid ethyl ester; AY 27255; RGH 4405; TCV 3B; V 6383; V6383_SIGMA; AY 27,255; Apovincaminate d'ethyle; Apovincaminate d'ethyle [French]; Cavinton (TN); Cis-Apovincaminic acid ethyl ester; Intelectol (TN); RGH-4405; TCV-3B; Ultra-Vinca; Vinpocetine-ethyl apovincaminate; Vinpocetinum [INN-Latin]; Eburnamenine-14-carboxylic acid ethyl ester; Ethyl apovincamin-22-oate; Vinpocetine [USAN:INN:JAN]; Ethyl (+)-apovincaminate; Vinpocetine (JAN/USAN/INN); Ethyl(+)-cis-apovincaminate; Ethyl apovincaminate, (3alpha,16alpha)-isomer; Ethyl (3alpha,16alpha)-eburnamenine-14-carboxylate; (+)-Apovincaminic acid ethyl ester; (+)-cis-Apovincaminic acid ethyl ester; (3alpha, 16alpha)-Eburnamenine-14-carboxylic acid ethyl ester; 1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine, eburnamenine-14-carboxylic acid deriv.; 3-alpha,16-alpha-Apovincaminic acid ethyl ester
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| Drug Type |
Small molecular drug
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| Indication | Ischemic stroke [ICD-11: 8B11.5Z; ICD-9: 434.91] | Approved | [1], [2] | |
| Therapeutic Class |
Vasodilator Agents
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| Structure |
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Download2D MOL |
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| Formula |
C22H26N2O2
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| Canonical SMILES |
CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC
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| InChI |
1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
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| InChIKey |
DDNCQMVWWZOMLN-IRLDBZIGSA-N
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| CAS Number |
CAS 42971-09-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855619, 3727081, 7848434, 7980299, 10299443, 10321872, 11341598, 11361781, 11364294, 11366856, 11369418, 11371881, 11374568, 11377580, 11466296, 11467416, 11485054, 11486071, 11487183, 11489345, 11490776, 11492889, 11495214, 14802886, 14925387, 17405811, 24278182, 26612408, 26680355, 26759739, 36887098, 47216903, 47365339, 47440398, 47810892, 47959906, 48334637, 48334638, 48416699, 48483328, 49698412, 49964760, 50103960, 50103961, 50103962, 50103963, 50113284, 53778363, 53790458, 56424092
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| ChEBI ID |
CHEBI:32297
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| SuperDrug ATC ID |
N06BX18
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| SuperDrug CAS ID |
cas=042971095
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vinpocetine can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.442; p = 0.018). | |||
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Studied Microbe: Clostridium sp.
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vinpocetine can be metabolized by Clostridium sp. (log2FC = -0.49; p = 0.027). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 1 (PDE1) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5285). | |||
| REF 2 | Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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