Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06AZJ
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| Former ID |
DNC007116
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| Drug Name |
4-cyclohexylamino-pyrimidine-2-carbonitrile
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| Synonyms |
2-Cyano-pyrimidine, 5; 4-(cyclohexylamino)pyrimidine-2-carbonitrile; CHEMBL221591; BDBM19749; 927176-94-1; 2-Pyrimidinecarbonitrile, 4-(cyclohexylamino)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H14N4
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| Canonical SMILES |
C1CCC(CC1)NC2=NC(=NC=C2)C#N
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| InChI |
1S/C11H14N4/c12-8-11-13-7-6-10(15-11)14-9-4-2-1-3-5-9/h6-7,9H,1-5H2,(H,13,14,15)
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| InChIKey |
UWPRHHHJGYCNGK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin K (CTSK) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Lysosome | |||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| Trafficking and processing of endosomal TLR | ||||
| MHC class II antigen presentation | ||||
| WikiPathways | RANKL/RANK Signaling Pathway | |||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. | |||
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