Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06AEO
|
|||
| Former ID |
DAP000906
|
|||
| Drug Name |
Cyproterone
|
|||
| Synonyms |
Ciproterona; Ciproterone; CyPat; Cyproteron; Cyproteronum; Ciproterona Servycal; Ciproterone [DCIT]; SH 80881; Apo-cyproterone; Ciproterona Servycal (TN); Ciproterona [INN-Spanish]; Cyproterone (INN); Cyproterone [INN:BAN]; Cyproteronum [INN-Latin]; Dianette (TN); Gen-Cyproterone; Novo-cyproterone; Diane-35 (TN); (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one; 6-Chlor-delta(6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron; 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron; 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron [German]; 6-chloro-17-hydroxy-1beta,2beta-dihydro-3'H-cyclopropa[1,2]pregna-4,6-diene-3,20-dione
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Prostate cancer [ICD-11: 2C82.0; ICD-10: C61; ICD-9: 185] | Approved | [1] | |
| Therapeutic Class |
Anticancer Agents
|
|||
| Company |
Schering-Plough
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C22H27ClO3
|
|||
| Canonical SMILES |
CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)O
|
|||
| InChI |
1S/C22H27ClO3/c1-11(24)22(26)7-5-14-12-9-18(23)17-10-19(25)13-8-16(13)21(17,3)15(12)4-6-20(14,22)2/h9-10,12-16,26H,4-8H2,1-3H3/t12-,13+,14-,15-,16-,20-,21-,22-/m0/s1
|
|||
| InChIKey |
DUSHUSLJJMDGTE-ZJPMUUANSA-N
|
|||
| CAS Number |
CAS 2098-66-0
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:50742
|
|||
| ADReCS Drug ID | BADD_D00554 | |||
| SuperDrug ATC ID |
G03HA01
|
|||
| SuperDrug CAS ID |
cas=002098660
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.659; p = 0.034). | |||
|
Studied Microbe: Bacteroides eggerthii DSM20697
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.461; p = 0.025). | |||
|
Studied Microbe: Bacteroides fragilis ATCC43859
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.466; p = 0.012). | |||
|
Studied Microbe: Bacteroides fragilis HMW 610
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.668; p = 0.017). | |||
|
Studied Microbe: Bacteroides fragilis HMW 615
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.516; p = 0.037). | |||
|
Studied Microbe: Bacteroides fragilis NCTC 9343
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.708; p = 0.01). | |||
|
Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.48; p = 0.03). | |||
|
Studied Microbe: Bacteroides fragilis str. DS-208
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.611; p = 0.004). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 3731
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.344; p = 0.043). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 7330
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.439; p = 0.009). | |||
|
Studied Microbe: Bacteroides uniformis ATCC 8492
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.628; p = 0.001). | |||
|
Studied Microbe: Bacteroides vulgatus ATCC 8482
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.685; p = 0.016). | |||
|
Studied Microbe: Bacteroides xylanisolvens DSM18836
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.474; p = 0.001). | |||
|
Studied Microbe: Odoribacter splanchnicus
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Odoribacter splanchnicus (log2FC = -0.515; p = 0.026). | |||
|
Studied Microbe: Parabacteroides distasonis ATCC 8503
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.426; p = 0.029). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Blautia hansenii DSM20583
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.544; p = 0.017). | |||
|
Studied Microbe: Clostridium sp.
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Cyproterone acetate can be metabolized by Clostridium sp. (log2FC = -0.61; p = 0.024). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drug information of Cyproterone, 2008. eduDrugs. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Coactivator selective regulation of androgen receptor activity. Steroids. 2009 Aug;74(8):669-74. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.