Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05YAS
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| Former ID |
DIB008696
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| Drug Name |
Tolafentrine
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| Synonyms |
BY-4070
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| Drug Type |
Small molecular drug
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| Indication | Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J44, J44.9] | Discontinued in Phase 2 | [1] | |
| Company |
ALTANA Pharma AG
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| Structure |
 |
Download2D MOL |
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| Formula |
C28H31N3O4S
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| Canonical SMILES |
CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)C3=NC4CCN(CC4C5=CC(=C(C=C53)OC)OC)C
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| InChI |
1S/C28H31N3O4S/c1-18-5-11-21(12-6-18)36(32,33)30-20-9-7-19(8-10-20)28-23-16-27(35-4)26(34-3)15-22(23)24-17-31(2)14-13-25(24)29-28/h5-12,15-16,24-25,30H,13-14,17H2,1-4H3/t24-,25-/m0/s1
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| InChIKey |
FVZJIAUYFDQQKJ-DQEYMECFSA-N
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| CAS Number |
CAS 139308-65-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 3 (PDE3) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003767) | |||
| REF 2 | Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration | |||
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