Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05WCI
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| Former ID |
DNCL001987
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| Drug Name |
ABT-384
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| Synonyms |
ABT-384; UNII-R5TH77F919; CHEMBL222670; ABT 384; R5TH77F919; SCHEMBL231595; GTPL7357; ABT384; SCHEMBL20457214; BDBM50195291; DB12501; 868623-40-9; 4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionylamino}-adamantane-1-carboxylic acid amide
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9] | Phase 2 | [1], [2] | |
| Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Phase 2 | [1], [2] | ||
| Company |
Abbott Laboratories
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| Structure |
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Download2D MOL
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| Formula |
C25H34F3N5O2
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| Canonical SMILES |
CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)N)N4CCN(CC4)C5=NC=C(C=C5)C(F)(F)F
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| InChI |
1S/C25H34F3N5O2/c1-23(2,33-7-5-32(6-8-33)19-4-3-18(14-30-19)25(26,27)28)22(35)31-20-16-9-15-10-17(20)13-24(11-15,12-16)21(29)34/h3-4,14-17,20H,5-13H2,1-2H3,(H2,29,34)(H,31,35)
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| InChIKey |
CLHMYBJIOZXCEX-UHFFFAOYSA-N
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| CAS Number |
CAS 868623-40-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7357). | |||
| REF 2 | ClinicalTrials.gov (NCT01137526) Efficacy and Safety Study of ABT-384 in Subjects With Mild-to-Moderate Alzheimer's Disease. U.S. National Institutes of Health. | |||
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