Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05VIL
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| Former ID |
DAP001407
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| Drug Name |
Nalmefene
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| Synonyms |
Alcofene; Arthene; Cervene; Cessal; Incystene; Nalmefeno; Nalmefenum; Nalmetrene; Nalmetreno; Nalmetrenum; Revex; Soberal; JF 1; ORF 11676; JF-1; NIH-10365; Nalmefeno [INN-Spanish]; Nalmefenum [INN-Latin]; Nalmetreno [INN-Spanish]; Nalmetrenum [INN-Latin]; ORF-11676; Revex (TN); Nalmefene (USAN/INN); Nalmefene [USAN:BAN:INN]; (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol; (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinon-3,14-diol; (5alpha)-17-(cyclopropylmethyl)-6-methylidene-4,5-epoxymorphinan-3,14-diol; 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol; 6-Desoxy-6-methylenenaltrexone; 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
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| Drug Type |
Small molecular drug
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| Indication | Opioid dependence [ICD-11: 6C43.2Z] | Approved | [1] | |
| Therapeutic Class |
Anticraving Agents
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| Company |
Eurohealth International Sarl
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| Structure |
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Download2D MOL |
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| Formula |
C21H25NO3
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| Canonical SMILES |
C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O
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| InChI |
1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1
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| InChIKey |
WJBLNOPPDWQMCH-MBPVOVBZSA-N
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| CAS Number |
CAS 55096-26-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10227, 855608, 11039366, 12013834, 14753624, 14875634, 24897753, 39317900, 47206836, 48259434, 48416306, 49992724, 50103951, 51025118, 57359131, 103256810, 103976649, 124800059, 126686477, 129588878, 134221999, 134338615, 135004339, 135650681, 137244646, 139813941, 144204424, 162173089, 162225811, 164230833, 164779663, 164830448, 170465281, 175267830, 179150613, 184585438, 223440476, 223673675, 223880913, 226421524, 241096138
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| ChEBI ID |
CHEBI:7457
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| ADReCS Drug ID | BADD_D01522 ; BADD_D01523 | |||
| SuperDrug ATC ID |
N07BB05
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor (OPR) | Target Info | Antagonist | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospin... J Pharmacol Exp Ther. 2009 Feb;328(2):588-97. | |||
| REF 3 | Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. Alcohol Clin Exp Res. 2008 Jul;32(7):1159-66. | |||
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