Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05TVU
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| Former ID |
DNC005066
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| Drug Name |
A-224940
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| Synonyms |
CHEMBL364377; A-224940; 635755-66-7; SCHEMBL5884420; CTK2A8845; DTXSID90623944; BDBM50152424; 8-(cyclohexylmethoxy)quinolin-2-amine; 8-Cyclohexylmethoxy-quinolin-2-ylamine; 2-Quinolinamine, 8-(cyclohexylmethoxy)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C16H20N2O
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| Canonical SMILES |
C1CCC(CC1)COC2=CC=CC3=C2N=C(C=C3)N
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| InChI |
1S/C16H20N2O/c17-15-10-9-13-7-4-8-14(16(13)18-15)19-11-12-5-2-1-3-6-12/h4,7-10,12H,1-3,5-6,11H2,(H2,17,18)
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| InChIKey |
OTJOSBTUERTNPP-UHFFFAOYSA-N
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| CAS Number |
CAS 635755-66-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melanin-concentrating hormone receptor 1 (MCHR1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4883-6. | |||
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