Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05SSJ
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| Former ID |
DIB012094
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| Drug Name |
Dotarizine
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| Synonyms |
Dotarazine; FI-6020; FI-6026
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Terminated | [1] | |
| Company |
Ferrer Internacional SA
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| Structure |
 |
Download2D MOL |
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| Formula |
C29H34N2O2
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| Canonical SMILES |
C1CN(CCN1CCCC2(OCCO2)C3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5
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| InChI |
1S/C29H34N2O2/c1-4-11-25(12-5-1)28(26-13-6-2-7-14-26)31-21-19-30(20-22-31)18-10-17-29(32-23-24-33-29)27-15-8-3-9-16-27/h1-9,11-16,28H,10,17-24H2
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| InChIKey |
LRMJAFKKJLRDLE-UHFFFAOYSA-N
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| CAS Number |
CAS 84625-59-2
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:138033
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2 receptor (5HT2R) | Target Info | Modulator | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Vasostabilizing effect of Dotarizine (Ca(2+)-channel blocker) on cerebrovascular reactivity in rabbits. Neurol Res. 2000 Mar;22(2):229-32. | |||
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