Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05RTV
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| Former ID |
DIB005436
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| Drug Name |
Superoxide dismutase
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| Synonyms |
Orgotein; HSOD, Yeda; Manganese SOD, Boehringer Ingelheim; NK-341; Orgotein, Yeda; SOD, Yeda; Superoxide dismutase, Boehringer Ingelheim; Superoxide dismutase, Nippon; Superoxide dismutase, Yeda; HSOD, Bio-Technology General; Orgotein, Bio-Technology General; SOD, Bio-Technology General; Superoxide dismutase, Bio-Technology
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| Indication | Myocardial infarction [ICD-11: BA41-BA43; ICD-9: 410] | Phase 2 | [1] | |
| Company |
Weizmann Institute of Science; Nippon Kayaku Co Ltd; Boehringer Ingelheim Corp
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Superoxide dismutase Cu-Zn (SOD Cu-Zn) | Target Info | Modulator | [2] |
| BioCyc | Reactive oxygen species degradation | |||
| KEGG Pathway | Peroxisome | |||
| Amyotrophic lateral sclerosis (ALS) | ||||
| Huntington's disease | ||||
| Prion diseases | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Pathwhiz Pathway | Degradation of Superoxides | |||
| Pathway Interaction Database | Validated nuclear estrogen receptor alpha network | |||
| FOXA1 transcription factor network | ||||
| Reactome | Platelet degranulation | |||
| Detoxification of Reactive Oxygen Species | ||||
| WikiPathways | Oxidative Stress | |||
| Copper homeostasis | ||||
| Detoxification of Reactive Oxygen Species | ||||
| Nifedipine Activity | ||||
| Amyotrophic lateral sclerosis (ALS) | ||||
| Dopamine metabolism | ||||
| AGE/RAGE pathway | ||||
| Folate Metabolism | ||||
| Vitamin B12 Metabolism | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Phase II trial of copper zinc superoxide dismutase (CuZn SOD) in the treatment of Crohn's disease. Free Radic Res Commun. 1991;12-13 Pt 2:563-9. | |||
| REF 2 | Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant.Artif Cells Blood Substit Immobil Biotechnol.2011 Jun;39(3):127-36. | |||
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