Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D05ROV
|
|||
Former ID |
DNC003892
|
|||
Drug Name |
GNF-PF-5411
|
|||
Synonyms |
CINCHONIDINE; Cinchonan-9-ol; cinchonine; alpha-Quinidine; 485-71-2; GNF-PF-5411; 118-10-5; MLS002637808; NSC5364; .alpha.-Quinidine; NSC 5364; Cinchonan-9-ol, (8.alpha.,9R)-; Cinchonan-9-ol, (9S)-; (8alpha,9R)Cinchonan-9-ol; a-quinidine; (8-alpha,9R)-Cinchonan-9-ol; EINECS 207-622-3; {5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)methanol; SMR001488502; AI3-15317; 4-quinolyl-(5-vinylquinuclidin-2-yl)methanol; 2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-; (+)-Quinolin-4-yl(5-vinylquinuclidin-2-yl)methanol
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C19H22N2O
|
|||
Canonical SMILES |
C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O
|
|||
InChI |
1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2
|
|||
InChIKey |
KMPWYEUPVWOPIM-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 485-71-2
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Debrisoquine 4-hydroxylase (CYP2D6) | Target Info | Inhibitor | [1] |
KEGG Pathway | Metabolism of xenobiotics by cytochrome P450 | |||
Drug metabolism - cytochrome P450 | ||||
Serotonergic synapse | ||||
Reactome | Xenobiotics | |||
WikiPathways | Metapathway biotransformation | |||
Tamoxifen metabolism | ||||
Oxidation by Cytochrome P450 | ||||
Vitamin D Receptor Pathway | ||||
Aripiprazole Metabolic Pathway | ||||
Fatty Acid Omega Oxidation | ||||
Codeine and Morphine Metabolism |
References | Top | |||
---|---|---|---|---|
REF 1 | Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.